Since I cast bullets, pretty much all I ever shoot in my handguns are my cast lead rounds.  So for 45, I shoot the Lee cast 230LRNs since they work in my 1911 and the SWCs don't.

What's your favorite 45 load for practice, plinking, or whatever?  Looking at Hodgdon.com for 45ACP 230LRNs, anywhere from 4.5 to 5.3 grains of W231 are ok, with COL 1.260".    Maybe the Speer was higher, don't recall for sure; I did read in one guide that 5.7 W231 was ok but I don't have my Speer guide in front of me.  WARNING- some of the loads here might be slightly in excess of published max loads, neither I nor WeTheArmed is responsible for what you do with this information. 

I worked up to 5.6 grains of W231 and here's what I got with my PACT chrony and a 4" Smith M&P45.  But I usually load at 5.3 W231.
4.3 W231 --> 653 fps
4.6 W231--> 711 fps
5.0 W231--> 750 fps
5.3 W231--> 794 fps
5.6 W231--> 875 fps

Accuracy seemed best between 4.6 and 5.6 grains of W231, I couldn't really tell a difference between those loads.  95% of the time when I'm making a couple hundred 45 for the range or practice, I'll make the 5.3 grains of W231 loads since I figure that's 230 grains going 800 fps and ought to be pretty close to the 830 fps Hodgdon says is standard speed for jacketed 230 grain bullets.

I use the Lee 230 TC over 4 grains of Red Dot for my normal target round.

I use nothing but W231 and usually load 5.2gr with a 230gr bullet.

Last few thousand I've been sticking with hard cast 200 gr RNFP over 5.1 gr of Unique.  Around 800 FPS or a little less out of my 5".  Nice and tame to shoot, you can burn through a few hundred without feeling like it's beating you to death.  I started with Unique because I had a bunch on hand from loading shotguns and just stuck with it.  Works well for me and doesn't seem to be much dirtier than anything else, unless you load very light.

I load a few 185 SWC with 5.8 gr and like those, but some of my pistols don't like to feed them.