The game is fun, but it is essentially Skyrim... So a sneaky archer will always be effective.
The crafting station for weapons is great. Find a gun you like? Put a longer barrel on it, put a heavier receiver on it, scope the sucker.
Don't waste the .45 ammo in the submachine guns. Just don't. It does 9 damage each that way, but if you run it through a modified combat rifle? well my regular carry does 75 per trigger pull.
Linking settlements will get you more supplies, people, and eventually money than you can use. But don't get too bogged down by it as it doesn't progress the story after the first little bit. Also... One you have the artillery unlocked... Stop listening to Preston. He's a nice guy but you will forever be doing milk runs, there is no end to the missions for him.
Sadly they don't want your power armor to be awesome for very long, so if you are playing on a computer (yes even a Mac) then you can fix it, if you are playing on something without a mouse you are at their mercy.
Also, don't forget to put equipment on your companions. They will never run out of ammo for their own weapon, but anything you equip on them will need bullets, so I usually buff their armor. PS, you can put them in the power armor, and they can move even without the power cores. Unless they patched that...
Also, for sheer playability, change your carry weight. Open the console and modify it. Bethesda is miserly in what they let you carry in these games. You can buff it a little, or do what I did and make it so I have virtually no limit to carry weight.