I just bought one with a 3.75 inch barrel and I used to have one with the 4 5/8 barrel. Between the two I would obviously go with the shorter one. If possible, I highly recommend the bisley style grip. It does a much better job of handling recoil. I also have a Blackhawk .45 with a 5.5 barrel. That seems to be the best compromise of accuracy, recoil management, and packability.